![]() ![]() Obesity has been recently recognized as a new disease and one of the leading health problems in the United States, associated with increased risk of cardiovascular disorders, diabetes and cancer. Our results reveal that bAT plays a role in breast cancer development in obesity. Also, bAT distal from the tumor is more inflamed in obese than in lean mice. In vivo experiments demonstrate that mammary tumors from obese mice are larger and that bAT from obese tumor-bearers contains higher numbers of macrophages/CLS and hypertrophic adipocytes than bAT from lean tumor-bearers, thus confirming it is more inflamed. Focus on the adipokine leptin, which has been shown to have a central role in breast cancer pathogenesis, indicated it modulates macrophage phenotypes and functions. In cell supernatants Luminex identified additional molecules with chemotactic and other pro-tumor functions. Macrophages were exposed to the adipocyte and tumor paracrine factors leptin, CCL2 and lauric acid (alone or in combinations). The effects of this interplay on macrophage chemotaxis were examined in vitro, using co-cultures of mouse macrophages, mammary tumor cells and adipocytes. We hypothesize that the breast AT (bAT) is inflamed in obese females and plays a major role in breast cancer development. However, the mammary gland contains adipose tissue (AT) which may enable the crosstalk between adipocytes and tumor cells contributing to tumor macrophage recruitment. ![]() The relationship between obesity and breast cancer (BC) has focused on serum factors. ![]()
0 Comments
Leave a Reply. |